Citations

2026
  • Chocarro, J., Marana, S., Espelosin, M. et al. Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease. npj Parkinsons Dis. 12, 72 (2026). doi: doi.org/10.1038/s41531-026-01289-9
2025
  • Tenreiro M, Mohana-Borges R, Sánchez-Sánchez S, Mantas Dias A, Blanch R, Muotri A. MeCP2 regulates telencephalic development in human cerebral organoids. Cell Reports 2025, 44 (12). doi: 10.1016/j.celrep.2025.116670
  • Palacios-Alonso D, Bazan-Peregrino M, Zalacain , Marrodán , Mato-Berciano A, Pérez-Larraya J, Ausejo-Mauleon I, Patiño-García A, Zavala-Romero L, Cascalló M, Alemany R, González-Huarriz M, and Alonso M. Toxicity and Biodistribution of the Oncolytic Virus VCN-01 Following Intracranial Injection in Syrian Hamsters. Human Gene Therapy, 2025 Sep 12; 36, No. 17-18. doi: 10.1177/10430342251372091
  • Cervera ST, Martínez S, Iranzo-Martínez M, de Mera RMM, Alonso J. Suicide gene therapy targeting ewing sarcoma via an ewing-specific GGAA promoter. Sci Rep. 2025 Aug 8;15(1):29020. doi: 10.1038/s41598-025-14945-6
  • Gaminde-Blasco A, Senovilla-Ganzo R, Balantzategi U, Martinez-Preciado M, Capetillo-Zarate E, García-Moreno F, Matute C, Baleriola J, Alberdi E.
    Disruption of hnRNP A2-mediated RNA dynamics by amyloid-β drives MBP increase in Alzheimer’s disease. Cell Mol Life Sci. 2025 Aug 2;82(1):298. doi: 10.1007/s00018-025-05823-5.
  • Brao A, Sánchez Á, Rodríguez I, Rey JD, Lope-Piedrafita S, Prat E, Nunes V, Chillón M, Estévez R, Bosch A. Gene therapy rescues brain edema and motor function in a mouse model of megalencephalic leukoencephalopathy with subcortical cysts. Mol Ther. 2025 Apr 2; 33(4):1434-1448. doi: 10.1016/j.ymthe.2025.02.046. Epub 2025 Mar 5. PMID: 40051162; PMCID: PMC11997501.
  • Roig-Soriano J, Edo Á, Verdés S, Martín-Alonso C, Sánchez-de-Diego C, Rodriguez-Estevez L, Serrano AL, Abraham CR, Bosch A, Ventura F, Jordan BA, Muñoz Cánoves P, Chillón M. Long-term effects of s-KL treatment in wild- type mice: Enhancing longevity, physical well-being, and neurological resilience. Mol Ther. 2025 Apr 2; 33(4):1449-1465. doi: 10.1016/j.ymthe.2025.02.030. Epub 2025 Feb 22.
  • Serra I, Martín-Monteagudo C, Sánchez Romero J, Quintanilla JP, Ganchala D, Arevalo MA, García-Marqués J, Navarrete M. Astrocyte ensembles manipulated with AstroLight tune cue-motivated behavior. Nat Neurosci. 2025 Mar;28(3):616-626. doi: 10.1038/s41593-025-01870-0. Epub 2025 Feb 3.
  • Nieto-Sanchez A, Martinez-Lage M, Puig-Serra P, Carpintero S, Alonso-Yanez A, Ojeda-Walczuk P, Ibañez-Navarro M, Pita G, Moya FJ, Moreno C, Martin MC, Alonso R, Nuñez-Torres R, Sanchez-Arevalo Lobo VJ, Alonso-Guirado L, Malats N, Gonzalez-Neira A, Fernandez L, Roda-Navarro P, Torres-Ruiz R, Rodriguez-Perales S. Selective genome editing of amplified oncogenes triggers immunogenic cell death and tumor remodeling. Mol Cancer (2025). https://doi.org/10.1186/s12943-025-02542-0
  • Esandi J, Renault P, Capilla-López MD, Blanch R, Edo Á, Ramirez-Gómez D, Bosch A, Almolda B, Saura CA, Giraldo J, Chillón M. HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer’s disease. Biomed Pharmacother. 2025 Jan 15;183:117815. doi: 10.1016/j.biopha.2025.117815. Epub ahead of print. PMID: 39818099.
2024
  • Ardanaz C, de la Cruz A, Minhas P, Hernández-Martín N, Pozo MA, Valdecantos MP, Valverde AM, Villa-Valverde P, Elizalde-Horcada M, Puerta E, Ramírez MJ, Ortega JE, Urbiola A, Ederra C, Ariz M, Ortiz-de-Solórzano C, Fernández-Irigoyen J, Santamaría E, Karsenty G, Brüning JC, Solas M. Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Science Advances, 2024 Oct 18;10(42):eadp1115. doi: 10.1126/sciadv.adp1115
  • Sebastián D, Beltrà M, Irazoki A, Sala D, Aparicio P, Aris C, Alibakhshi E, Rubio-Valera M, Palacín M, Castellanos J, Lores L, Zorzano A. TP53INP2- dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging. Autophagy. 2024 Aug;20(8):1815-1824. doi:10.1080/15548627.2024.2333717. Epub 2024 Mar 28.
  • Bunuales M, Garduno A, Chillon M, Bosch A, Gonzalez-Aparicio M, Espelosin M, Garcia-Gomara M, Rico AJ, Garcia-Osta A, Cuadrado-Tejedor M, Lanciego JL, Hernandez-Alcoceba R. Characterization of brain transduction capability of a BBB-penetrant AAV vector in mice, rats and macaques reveals differences in expression profiles. Gene Ther. 2024 Sep;31(9-10):455-466. doi: 10.1038/s41434-024-00466-w. Epub 2024 Jul 22. PMID: 39039204; PMCID: PMC11399087.
  • Fitzgerald MQ, Chu T, Puppo F, Blanch R, Chillón M, Subramaniam S, Muotri AR. Generation of ‘semi-guided’ cortical organoids with complex neural oscillations. Nat Protoc. 2024 Sep;19(9):2712-2738. doi: 10.1038/s41596-024-00994-0. Epub 2024 May 3. Erratum in: Nat Protoc. 2024 Oct 15. doi: 10.1038/s41596-024-01087-8. PMID: 38702386; PMCID: PMC11380594.
2023
  • Johann, L., Soldati, S., Müller, K., Lampe, J., Marini, F., Klein, M., Schramm, E., Ries, N., Schelmbauer, C., Palagi, I., Karram, K., Assmann, J. C., Khan, M. A., Wenzel, J., Schmidt, M. H. H., Körbelin, J., Schlüter, D., van Loo, G., … Waisman, A. (2023). A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS. Journal of Clinical Investigation, 133(24), e168314. https://doi.org/10.1172/JCI168314
  • Chocarro, J., Rico, A. J., Ariznabarreta, G., Roda, E., Honrubia, A., Collantes, M., Peñuelas, I., Vázquez, A., Rodríguez-Pérez, A. I., Labandeira-García, J. L., Vila, M., & Lanciego, J. L. (2023). Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates. Brain, 146(12), 5000–5014. https://doi.org/10.1093/brain/awad331
  • Roig-Soriano, J., Sánchez-de-Diego, C., Esandi-Jauregui, J., Kentsis, A., Chen, Z., & Brunner, M. (2023). Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure. *Scientific Reports, 13*, 4211. https://doi.org/10.1038/s41598-023-31117-6
  • Mielcarek, M., & Isalan, M. (2023). A minimal region of the HSP90AB1 promoter is suitable for ubiquitous expression in different somatic tissues with applicability for gene therapy. *Frontiers in Molecular Biosciences, 10*, 1175407. https://doi.org/10.3389/fmolb.2023.1175407
  • Gonzalez-Sepulveda, M., Compte, J., Cuadros, T., Nicolau, A., Guillard-Sirieix, C., Peñuelas, N., Lorente-Picon, M., Parent, A., Romero-Giménez, J., Cladera-Sastre, J. M., Laguna, A., & Vila, M. (2023). In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease. Brain, 146(3), 1040–1052. https://doi.org/10.1093/brain/awac445
2022
  • Serra, I., Esparza, J., Delgado, L., et al. (2022). Ca2+-modulated photoactivatable imaging reveals neuron-astrocyte glutamatergic circuitries within the nucleus accumbens. Nature Communications, 13, 5272. https://doi.org/10.1038/s41467-022-33020-6
  • Edo, Á., Calvo-Barreiro, L., Eixarch, H., Bosch, A., Chillón, M., & Espejo, C. (2022). Therapeutic effect of IL-21 blockage by gene therapy in experimental autoimmune encephalomyelitis. *Neurotherapeutics, 19*(5), 1617-1633. https://doi.org/10.1007/s13311-022-01279-8
  • Roig-Soriano, J., Griñán-Ferré, C., Espinosa-Parrilla, J. F., Abraham, C. R., Bosch, A., Pallàs, M., & Chillón, M. (2022). AAV-mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice. Aging Cell, 21(4), e13581. https://doi.org/10.1111/acel.13581
  • Pignatelli, J., de Sevilla, M. E. F., Sperber, J., Horrillo, D., Medina-Gomez, G., & Aleman, I. T. (2022). Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons. International Journal of Molecular Sciences, 23(9), 4679. https://doi.org/10.3390/ijms23094679
  • Fernández de Sevilla, M. E., Pignatelli, J., Zegarra-Valdivia, J. A., Mendez, P., Nuñez, A., & Torres Alemán, I. (2022). Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons. Molecular Psychiatry, 27(4), 2182-2196. https://doi.org/10.1038/s41380-022-01442-9
2021
  • Kagiava, A., Richter, J., Tryfonos, C., Leal-Julià, M., Sargiannidou, I., Christodoulou, C., Bosch, A., & Kleopa, K. A. (2021). Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery. *Scientific Reports, 11*(1), 23358. https://doi.org/10.1038/s41598-021-02694-1
2020
  • Domingo-Rodriguez, L., Ruiz de Azua, I., Dominguez, E., et al. (2020). A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nature Communications, 11, 782. https://doi.org/10.1038/s41467-020-14458-y
2019
  • Carballo-Carbajal, I., Laguna, A., Romero-Giménez, J., et al. (2019). Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis. Nature Communications, 10, 973. https://doi.org/10.1038/s41467-019-08858-y